Tissue distribution and expression of signaling lymphocyte activation molecule receptor to peste des petits ruminant virus in goats detected by real-time PCR
Identifieur interne : 002509 ( Main/Exploration ); précédent : 002508; suivant : 002510Tissue distribution and expression of signaling lymphocyte activation molecule receptor to peste des petits ruminant virus in goats detected by real-time PCR
Auteurs : Xuelian Meng [République populaire de Chine] ; Yongxi Dou [République populaire de Chine] ; Junjun Zhai [République populaire de Chine] ; Hairui Zhang [République populaire de Chine] ; Fengchao Yan [République populaire de Chine] ; Xiaoni Shi [République populaire de Chine] ; Xuelong Luo [République populaire de Chine] ; Hui Li [République populaire de Chine] ; Xuepeng Cai [République populaire de Chine]Source :
- Journal of Molecular Histology [ 1567-2379 ] ; 2011-10-01.
Descripteurs français
- Wicri :
- topic : Caprin.
English descriptors
- KwdEn :
Abstract
Abstract: In the present study, we investigated the tissue distribution and expression of signaling lymphocyte activation molecule (SLAM) in 40 tissues and organs of goats by real-time RT-PCR, in order to determine the role of these receptors in tissue tropism. SLAM mRNA was detected in all the samples investigated. The expression of SLAM mRNA was detected at high levels in spleen, mesenteric lymph node, hilar lymph node, mandibular lymph node, superficial cervical lymph node, nasal mucosa, duodenum, heart, gallbladder, thymus and blood; this is similar to the tissue tropism of peste des petits ruminant virus. However, it was surprising that expression of SLAM was low in lungs, colon and rectum which are the major sites of replication of PPRV. In addition, very low levels were detected in larynx, tongue and esophagus, which suggest the possible presence of an alternative receptor for PPRV. This study provided the first data on caprine SLAM for use in further studies of the pathogenesis of PPRV in goats.
Url:
DOI: 10.1007/s10735-011-9352-4
Affiliations:
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<front><div type="abstract" xml:lang="en">Abstract: In the present study, we investigated the tissue distribution and expression of signaling lymphocyte activation molecule (SLAM) in 40 tissues and organs of goats by real-time RT-PCR, in order to determine the role of these receptors in tissue tropism. SLAM mRNA was detected in all the samples investigated. The expression of SLAM mRNA was detected at high levels in spleen, mesenteric lymph node, hilar lymph node, mandibular lymph node, superficial cervical lymph node, nasal mucosa, duodenum, heart, gallbladder, thymus and blood; this is similar to the tissue tropism of peste des petits ruminant virus. However, it was surprising that expression of SLAM was low in lungs, colon and rectum which are the major sites of replication of PPRV. In addition, very low levels were detected in larynx, tongue and esophagus, which suggest the possible presence of an alternative receptor for PPRV. This study provided the first data on caprine SLAM for use in further studies of the pathogenesis of PPRV in goats.</div>
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<name sortKey="Cai, Xuepeng" sort="Cai, Xuepeng" uniqKey="Cai X" first="Xuepeng" last="Cai">Xuepeng Cai</name>
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<name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name>
<name sortKey="Luo, Xuelong" sort="Luo, Xuelong" uniqKey="Luo X" first="Xuelong" last="Luo">Xuelong Luo</name>
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<name sortKey="Yan, Fengchao" sort="Yan, Fengchao" uniqKey="Yan F" first="Fengchao" last="Yan">Fengchao Yan</name>
<name sortKey="Zhai, Junjun" sort="Zhai, Junjun" uniqKey="Zhai J" first="Junjun" last="Zhai">Junjun Zhai</name>
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